English Italiano

Biological Resources Center

Established in 2014 by the Departments of Oncology and Cardiovascular Research, the Mario Negri Institute Biological Resources Center (BRC) collects and stores biological samples and related data for the purposes of biomedical research. The objectives of the BRC include direct research with its own samples but also providing the scientific community with high-quality biological samples for biomedical research, collected with patients’ consent and stored according to current ethical and regulatory rules meeting the highest technological standards.

The BRC ensures maximum safety in the management of personal data from donors, as required by current regulations.

The BRC currently comprises several biobanks:

  • PANDORA stores biological samples (blood, plasma and tumor tissues) collected during surgical operations from patients with malignant epithelial ovarian cancer. The Pandora biobank was created with the aim of discovering and integrating molecular data (currently obtained with the “omics” techniques), with clinical variables, to identify diagnostic and prognostic molecular features, so as to improve the treatment of malignant epithelial ovarian cancer.
    Coordinator: Sergio Marchini, sergio.marchini@marionegri.it

  • SATURNE 1 stores biological samples (blood, plasma, serum and urine) collected during clinical pharmacological studies in cardiovascular diseases (heart failure, acute myocardial infarction, atrial fibrillation, heart surgery, diabetes mellitus) and intensive care (severe sepsis, traumatic brain injury, neurosurgery). The biobank’s ambition is to contribute to the discovery and clinical development of biological markers (biomarkers) that will help improve the early diagnosis and treatment of these diseases.
    Coordinator: Serge Masson, serge.masson@marionegri.it

  • SATURNE 2 stores blood samples collected for research on the genetic components of cardiovascular diseases. It covers three large populations: two are patients enrolled in the GISSI-HF and GISSI-Prevenzione clinical trials, in heart failure and myocardial infarction, respectively, and the third are healthy controls (blood donors) enrolled in the PROCARDIS study. This biobank provides opportunities to study the mechanisms involved in the development of cardiovascular diseases and related complications, with the aim of boosting our knowledge on the role of genetic factors.
    Coordinator: Maria Grazia Franzosi, mariagrazia.franzosi@marionegri.it

The Biobank of the Aldo e Cele Daccò Clinical Research Centre for Rare Diseases (Ranica, BG) stores biological samples for research (DNA, blood, plasma, serum, urine). The biobank has two sections, Rare Diseases and Kidney Diseases. This biobank ensures the availability of materials for research, to identify mutations underlying unusual and complex diseases, and identify biomarkers with diagnostic or prognostic value, possibly serving to develop new therapeutic approaches.

To ensure the procedures are for the use of biological samples of the highest quality, the Mario Negri BRC has implemented since 2014 a quality management system UNI EN ISO 9001 for the following: collection, storage and distribution of biological samples and related data for scientific research. The Mario Negri BRC is partner in the Biobanking and Biomolecular Resources Research Infrastructure (BBMRI).