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Nanobiology Unit

Research activities

• Nanotox: Understanding the impact of nanomaterials on biological matrices to assess the risk.

• Nanopharma: Understanding the interaction between nanocarriers and biological target to optimize the development of nanodrugs.

• Nanodiagnostics: Non-invasive imaging in rodents to develop innovative nanodiagnostics.


Main research projects:

• " Framework to respond to regulatory needs of future nanomaterials and markets" - Framework Project Seven (2013-2017).

• “Smart Nanoparticles For Boosted Drug Brain Targeting” - Research Enhancement Package Grants, CEN foundation. (2013-2015).

• NUTEC - New Technologies for the treatment of brain aging based on the use of nanocarriers, adult mesenchymal cells, and their effectors. Bando RL-MIUR 2011 (2013-2015).

Selected publications

  • Code: 15095
    Sitia L, Paolella K, Romano M, Violatto M B, Ferrari Raffaele, Fumagalli S, Colombo L, Bello E, De Simoni M G, D'Incalci M, Morbidelli M, Erba E, Salmona M, Moscatelli D, Bigini P
    An integrated approach for the systematic evaluation of polymeric nanoparticles in healthy and diseased organisms
    J Nanopart Res 2014; 16: 2481
    IF: 2.184
    Status: Published
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  • Code: 14124
    Ferrari Raffaele, Lupi M, Falcetta F, Bigini P, Paolella K, Fiordaliso F, Bisighini C, Salmona M, D'Incalci M, Morbidelli M, Moscatelli D, Ubezio P
    Integrated multiplatform method for in vitro quantitative assessment of cellular uptake for fluorescent polymer nanoparticles
    Nanotechnology 2014; 25: 045102
    IF: 3.821
    Status: Published
    PubMed icon
  • Code: 14943
    Schaffler M, Sousa F, Wenk A, Sitia L, Hirn S, Schleh C, Haberl N, Violatto M B, Canovi M, Andreozzi P, Salmona M, Bigini P, Kreyling W G, Krol S
    Blood protein coating of gold nanoparticles as potential tool for organ targeting
    Biomaterials 2014; 35: 3455-3466
    IF: 8.557
    Status: Published
    PubMed icon
  • Code: 14762
    Bigini P, Previdi S, Casarin E, Silvestri D, Violatto M, Facchin S, Sitia L, Rosato A, Zuccolotto G, Realdon N, Fiordaliso F, Salmona M, Morpurgo M
    In vivo fate of Avidin-Nucleic Acid Nanoassemblies as multifuctional diagnostic tools
    ACS Nano 2014; 8: 175-187
    IF: 12.881
    Status: Published
    PubMed icon
  • Code: 14454
    Cova L, Bigini P, Diana V, Sitia L, Ferrari Raffaele, Pesce R M, Khalaf R, Bossolasco P, Ubezio P, Lupi M, Tortarolo M, Colombo L, Giardino D, Silani V, Morbidelli M, Salmona M, Moscatelli D
    Biocompatible fluorescent nanoparticles for in vivo stem cell tracking
    Nanotechnology 2013; 24: 245603
    IF: 3.672
    Status: Published
    PubMed icon