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Experimental Neurology

The main research activities are devoted to characterize the molecular and biochemical mechanisms involved in the genesis and propagation of seizures in epilepsy with the aim of finding novel targets to develop new drugs or therapeutic strategies more effective and with limited side-effects. We use experimental models of seizures and epileptogenesis in rodents with particular attention to seizures involving in the limbic system and associated to neurodegeneration of specific neuronal populations. This type of seizures in humans are often refractory to classical anticonvulsant drugs.

Units

Selected publications

  • Code: 14464
    Balosso S, Liu J, Bianchi M E, Vezzani A
    Disulfide-containing high mobility group box-1 promotes N-methyl-d-aspartate receptor function and excitotoxicity by activating toll-like receptor 4-dependent signaling in hippocampal neurons
    Antioxid Redox Signal 2014; 21: 1726-1740
    IF: 7.407
    Status: Published
    PubMed icon
  • Code: 14023
    Iori V, Maroso M, Rizzi M, Iyer A, Vertemara R, Carli M, Agresti A, Antonelli A, Bianchi M E, Aronica E, Ravizza T, Vezzani A
    Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures
    Neurobiol Dis 2013; 58: 102-114
    IF: 5.202
    Status: Published
    PubMed icon
  • Code: 12900
    Vezzani A, French J, Bartfai T, Baram T Z
    The role of inflammation in epilepsy
    Nat Rev Neurol 2011; 7: 31-40
    IF: 12.461
    Status: Published
    PubMed icon
  • Code: 12175
    Maroso M, Balosso S, Ravizza T, Liu J, Aronica E, Iyer A M, Rossetti C, Molteni M, Casalgrandi M, Manfredi A A, Bianchi M E, Vezzani A
    Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    Nat Med 2010; 16: 413-419
    IF: 25.43
    Status: Published
    PubMed icon
  • Code: 11338
    Noè F, Pool A H, Nissinen J, Gobbi M, Bland R, Rizzi M, Balducci C, Ferraguti F, Sperk G, During M J, Pitkanen A, Vezzani A
    Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy
    Brain 2008; 131: 1506-1515
    IF: 9.603
    Status: Published
    PubMed icon