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Inflammation and Nervous System Diseases

The laboratory of Inflammation and Nervous System Diseases has extensive experience in in vivo and in vitro models of nervous system diseases including stroke and brain trauma. Presently the main scientific interests include the pathogenesis of cerebral ischemia and traumatic brain injury and the identification of novel protective strategies through the manipulation of the inflammatory response. 

 

Selected publications

  • Code: 16496
    Fumagalli S, Perego C, Zangari R, De Blasio D, Oggioni M, De Nigris F, Snider F, Garred P, Ferrante A M, De Simoni M G
    Lectin pathway of complement activation is associated with vulnerability of atherosclerotic plaques
    Front Immunol 2017; 8: 288
    IF: 5.511
    Status: Published
    PubMed icon
  • Code: 15826
    De Blasio D, Fumagalli S, Longhi L, Orsini F, Palmioli A, Stravalaci M, Vegliante G, Zanier E R, Bernardi A, Gobbi M, De Simoni M G
    Pharmacological inhibition of mannose binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury
    J Cereb Blood Flow Metab 2017; 37: 938-950
    IF: 6.045
    Status: Published
    PubMed icon
  • Code: 15683
    Zanier E R, Marchesi F, Ortolano F, Perego C, Arabian M, Zoerle T, Sammali E, Pischiutta F, De Simoni M G
    Fractalkine receptor deficiency is associated with early protection, but late worsening of outcome following brain trauma in mice
    J Neurotrauma 2016; 33: 1060-1072
    IF: 5.19
    Status: Published
    PubMed icon
  • Code: 16471
    Fumagalli S, De Simoni M G
    Lectin complement pathway and its bloody interactions in brain ischemia
    Stroke 2016; 47: 3067-3073
    IF: 6.032
    Status: Published
    PubMed icon
  • Code: 15978
    Perego C, Fumagalli S, Zanier E R, Carlino E, Panini N, Erba E, De Simoni M G
    Macrophages are essential for maintaining a M2 protective response early after ischemic brain injury
    Neurobiol Dis 2016; 96: 284-293
    IF: 5.02
    Status: Published
    PubMed icon
  • Code: 15896
    Orsini F, Chrysanthou E, Dudler T, Cummings J, Takahashi M, Fujita T, Demopulos G, De Simoni M G, Schwaeble W
    Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1
    J Neuroinflammation 2016; 13: 213
    IF: 5.102
    Status: Published
    PubMed icon
  • Code: 15751
    Pischiutta F, Brunelli L, Romele P, Silini A, Sammali E, Paracchini L, Marchini S, Talamini L, Bigini P, Boncoraglio G B, Pastorelli R, De Simoni M G, Parolini O, Zanier E R
    Protection of brain injury by amniotic mesenchymal stromal cell-secreted metabolites
    Crit Care Med 2016; 44: e1118-e1131
    IF: 7.05
    Status: Published
    PubMed icon
  • Code: 15883
    Goti G, Palmioli A, Stravalaci M, Sattin S, De Simoni M G, Gobbi M, Bernardi A
    Scaffold optimization of tetravalent antagonists of the mannose binding lectin
    Chemistry 2016; 22: 3686-3691
    IF: 5.317
    Status: Published
    PubMed icon
  • Code: 15497
    Llovera G, Hofmann K, Roth S, Salas-Perdomo A, Ferrer-Ferrer M, Perego C, Zanier E R, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, De Simoni M G, Dirnagl U, Planas A M, Plesnila N, Vivien D, Liesz A
    Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia
    Sci Transl Med 2015; 7: 299ra121
    IF: 16.264
    Status: Published
    PubMed icon
  • Code: 15578
    Fumagalli S, Perego C, Pischiutta F, Zanier E R, De Simoni M G
    The ischemic environment drives microglia and macrophage function
    Front Neurol 2015; 6: 81
    IF: 3.184
    Status: Published
    PubMed icon
  • Code: 15149
    Fumagalli S, Ortolano F, De Simoni M G
    A close look at brain dynamics: Cells and vessels seen by in vivo two-photon microscopy
    Prog Neurobiol 2014; 121: 36-54
    IF: 9.992
    Status: Published
    PubMed icon
  • Code: 14523
    Zanier E R, Zangari R, Munthe-Fog L, Hein E, Zoerle T, Conte V, Orsini F, Tettamanti M, Stocchetti N, Garred P, De Simoni M G
    Ficolin-3 mediated lectin complement pathway activation in subarachnoid hemorrhage patients
    Neurology 2014; 82: 126-134
    IF: 8.185
    Status: Published
    PubMed icon
  • Code: 13811
    Orsini F, Villa P, Parrella S, Zangari R, Zanier E R, Gesuete R, Stravalaci M, Fumagalli S, Ottria R, Reina J J, Paladini A, Micotti E, Ribeiro-Viana R, Rojo J, Pavlov V I, Stahl G L, Bernardi A, Gobbi M, De Simoni M G
    Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia
    Circulation 2012; 126: 1484-1494
    IF: 15.202
    Status: Published
    PubMed icon
  • Code: 12809
    Zanier E R, Montinaro M, Vigano' M, Villa P, Fumagalli S, Pischiutta F, Longhi L, Leoni M L, Rebulla P, Stocchetti N, Lazzari L, De Simoni M G
    Human umbilical cord blood mesenchymal stem cells protect mice brain after trauma
    Crit Care Med 2011; 39: 2501-2510
    IF: 6.33
    Status: Published
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  • Code: 11102
    Gesuete R, Storini C, Fantin A, Stravalaci M, Zanier E R, Orsini F, Vietsch H, Mannesse M L, Ziere B, Gobbi M, De Simoni M G
    Recombinant C1 inhibitor in brain ischemic injury
    Ann Neurol 2009; 66: 332-342
    IF: 9.935
    Status: Published
    PubMed icon