The membrano proliferative glomerulonephritis (MPGN) and C3 glomerulopathy (C3G) are rare causes of chronic nephritis and nephrotic syndrome that occur principally in children and young adults. MPGN/C3G are characterized by proteinuria, nephrotic syndrome, hematuria and chronic renal failure which can develop to end stage renal failure (ESRF). Based on immunofluorescence staining and ultrastructural appearance, C3 glomerulopathy can be further divided in:
- C3 glomerulonephritis (C3GN)
- Dense Deposits Disease (DDD)
In 2006 the MPGN/C3G Registry has been established under the coordination of the Clinical Research Center for Rare Diseases Aldo e Cele Daccò. Till now more than 440 cases of MPGN/C3G have been referred to the Registry from around 50 Units of Nephrology.
Clinical data of all patients referred to the Registry are collected by a form.
• Collecting clinical and genetic data of patients with MPGN/C3G
• Studying the genetic and biochemical abnormalities of MPGN/C3G
• Finding the best therapeutic approach for patients
Elena Bresin, MD
Erica Daina, MD
Sara Gamba, RN
Clinical Research Center for Rare Diseases Aldo e Cele Daccò Mario Negri Institute for Pharmacological Research IRCCS
Via G.B. Camozzi, 3 - 24020 Ranica (BG)
phone 0039 35 4535304
Fax 0039 35 4535392