The areas of interest are the study of haemodynamics in the onset of vascular diseases,medical imaging and computer science for clinical research. The research activities are carried out using engineering methods in clinical research, such as computational simulations, numerical processing of radio-diagnostic images and use of programming languages to develop information systems. The Laboratory is located in Ranica, named after Aldo e Cele Daccò, and includes the Clinical Research Informatics Unit.
The Clinical Research Informatics Unit develops applications for the management of clinical data generated in controlled clinical trials and medical records for the outpatient Clinic of the Daccò Centre. It also manages IT resources and provides Help Desk and video-conference support to the staff of the Centre.
Role of the hemodynamic forces in the development of cardiovascular diseases
This research line focuses on the study of the forces generated by the flow and the pulsation of blood on the arterial wall. Owing to recent advanced technologies in the field of medical imaging and mathematical modelling it is now possible to accurately reproduce the distribution of haemodynamic stresses at patient level. We first reconstruct the three-dimensional shape of the vessel, and then run numerical simulations of blood motion in these patient-specific geometries. Ongoing studies are in three main areas: atherosclerosis at the level of carotid bifurcation, cerebral aneurysmal pathology and complications of the vascular access for haemodialysis.
Informatic systems development in support of controlled clinical trial and of clinical activity
Successful Digital Transformation requires IT services to be delivered in a fast, agile and streamlined manner across the entire organization. This can present many challenges, but more importantly allows for huge opportunities to improve efficiencies across our Research Clinic. On the one hand, the Clinical Research Informatics Unit developed the medical record system for managing the clinical activities in the Centre. The main purpose of this huge project is to integrate under a single, centralised system, all clinical data generated in the Day Hospital with data collected in other Laboratories involved in clinical research (biochemical analyses, genetic analyses and biological banks). On the other hand, numerous controlled clinical trials are carried out in the Daccò Centre. These require high quality standards in the process of collection and management of clinical data. The Clinical Research Informatics Unit has developed a showcase site for clinical trials carried out in the Centre (http://clintrials.marionegri.it/). The platform includes a framework for the creation of electronic case report form (e-CRF), a system for conducting clinical monitoring and a tool for subjects’ randomization. At present, all clinical studies of the Daccò Centre are conducted using e-CRF via web.
International Consensus on Cardiopulmonary Resuscitation.