The areas of interest are the role of hemodynamics in the onset of vascular diseases and informatics for clinical research. The research activities are carried out using engineering methods in clinical research, such as computational modelling and use of programming languages to develop information systems. The Laboratory is located in the Clinical Research Centre in Ranica named after Aldo e Cele Daccò.
The Clinical Research Informatics Unit develops applications for the management of clinical data generated in controlled trials performed at the Daccò Centre. It manages the Information Technology resources providing Help Desk and video-conference support to the staff of the Centre.
Role of the hemodynamic forces in the development of cardiovascular diseases
This research line is aimed at studying the forces generated by the flowing blood on the arterial wall. Owing to recent advancements in medical imaging and mathematical modelling is now possible to accurately reproduce the distribution of hemodynamic stresses at patient level. We first reconstruct the three-dimensional shape of the vessel, and then run numerical simulations of blood in these patient-specific geometries. Ongoing studies are in three main areas: atherosclerosis at the level of carotid bifurcation, cerebral aneurysmal pathology, and complications of the vascular access for haemodialysis.
Informatic systems development in support of controlled clinical trial and of clinical activity
Successful digital transformation requires IT services to be delivered in a fast, agile, and streamlined manner across the entire organization. This process can pose many challenges, but it allows to increase efficiency across our Research Clinic. On the one hand, the Clinical Research Informatics Unit developed the medical record system for managing the clinical activities in the Centre. The main aim of this project is to integrate under a fast centralised system, all clinical data generated in the Day Hospital with data collected in other Laboratories involved in clinical research (biochemical and genetic analyses, and biological banks). On the other hand, numerous controlled clinical trials are carried out in the Daccò Centre. These require high quality standards for collecting, managing, and reporting clinical data. The Clinical Research Informatics Unit has developed a platform for the controlled clinical trials carried at Mario Negri Institute, including a framework for the creation of e-CRFs, a system for conducting clinical monitoring and a randomization tool.
International Consensus on Cardiopulmonary Resuscitation.