The laboratory deals with the monitoring of toxic factors (such as dioxins, PCBs, PAHs, endocrine disruptors,pesticides, heavy metals) in the environment and in workplace. Furthermore, it evaluates the exposure of human to health and environmental risks, through in silico and in vitro toxicity models. Based on the investigation of exposure and of effects, the risk is estimated using an integrated algorithm. Software for health and environmental effects have been developed in collaboration with US EPA and European authorities (www.vega-qsar.eu; www.toxread.eu).
Reduction of the environmental and toxicological impact of chemicals
We are daily exposed to thousands of substances that have potential risks for human health and for the environment. Current knowledge about mechanisms of toxicological processes regarding substances of industrial origin, cosmetics, pesticides, food additives, biocides, etc. is very poor. Through the systematic use of in silico methods, supported by in vitro methods, these effects could be estimated for dozens of environmental, ecotoxicological and toxicological properties. These methods are available for free at www.vegahub.eu, and could be used for regulatory evaluations. This allows to take advantage of the most of the information available and obtainable about chemicals.
Identification of substitutes for substances of greater risk
The impact of contaminants and undesired chemicals is a risk. Currently potential side effects of pollutants are discovered afterwards. Moreover, an effective strategy which could minimize the harmful effects on humans and on the environment lacks. The innovative use of implicit information about damaging properties of substances would reduce these harmful effects. By availing of software, developed within international projects, the preparation of new chemical compounds could be addressed towards increasingly compatible solutions, with the desired characteristics. This is possible thanks to the availability of rapid informatics tools, predictive for dozens of properties of interest.
International Consensus on Cardiopulmonary Resuscitation.