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Biochemistry and Molecular Pharmacology

Laboratory of Signal transduction

Head
Ester
Zito
Head of Laboratory
Biochemistry and Molecular Pharmacology
ester.zito@marionegri.it
Senior Advisor
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We focus on the study of the altered oxide-reductive balance, that influences protein folding and calcium homeostasis, inducing deterioration of muscle cells.

More specifically, we analyse the role of SEPN1 protein, whose alterations generate a rare myopathy. We study the association between modifications in SEPN1 andendoplasmic reticulum stress. The ultimate aim is the development of a pharmacological strategy for the treatment of SEPN1-related myopathy.

This laboratory also investigates how the endoplasmic reticulum stress affects the aggressiveness of different tumors to suggest some useful targets for the development of effective cancer therapies.

RESEARCH AREAS

Study of SEPN1 function, a protein associated with a rare myopathy

Development of a pharmacological strategy for the treatment of SEPN1-related myopathy

Study of the connection between endoplasmic reticulum stress and tumor aggressiveness

Head Unit
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Staff
Alessia Celeste
Marchetti
Researcher
alessia.marchetti@marionegri.it
Serena
Germani
Researcher
serena.germani@marionegri.it
Mhuammad
Niah
Researcher
Ersilia
Varone
Researcher
ersilia.varone@marionegri.it
Alexander L.
Chernorudskiy
Researcher
alexander.chernorudskiy@marionegri.it
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Codice:

International Consensus on Cardiopulmonary Resuscitation.

1205
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Head
Ester
Zito
Head of Laboratory
Biochemistry and Molecular Pharmacology
ester.zito@marionegri.it
Senior Advisor
No items found.

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