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Laboratory of Molecular Biology

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This laboratory is committed to the definition of the molecular effects of retinoic acid and its derivatives (retinoids), that are non-conventional drugs with differentiating ability of breast and gastric cancer cells.

New diagnostic methods to select patients who may benefit most from retinoid-based treatments are also investigated. Moreover, this laboratory has previously determined the structure of genes encoding different molybdoenzymes.

The ongoing studies are aimed to define their physiological function.

RESEARCH AREAS

Breast cancer: predictive diagnostic models for the clinical use of retinoic acid

Identification of predictive biomarkers able to select breast cancer patients who may benefit from retinoic acid-based therapies.

Clinical trials to test the efficacy of retinoid-based therapies against breast cancer

Phase III clinical trial in postmenopausal patients with estrogen receptor-positive breast cancer to assess the efficacy of adding retinoic acid to standard treatment.

Personalised therapy for breast cancer patients

Identification of protein networks specifically altered by retinoic acid in breast cancer cells to develop new therapeutic strategies based on drug combination as personalised treatments.

Preclinical study about retinoic acid against stomach cancer

Use of experimental models of stomach cancer to evaluate the therapeutic potential of retinoic acid in personalised treatments of this tumor type.

Studies about molybdoenzymes

Development of experimental models in vitro and in vivo aimed to define the physiological functions of the various members of the molybdoenzyme family.

Study of the molecular mechanisms of Cornelia de Lange Syndrome, a rare disease affecting children

Cornelia de Lange Syndrome is a rare disease that affects mainly children causing defects in the development of various organs including the heart, liver, eye as well as the central and peripheral nervous system. The main objective of the research is the study of the molecular mechanisms underlying this rare disease, using in vitro systems and induced pluripotent stem cells (iPSC), in order to identify molecular targets that could be "hit" with new therapeutic strategies.

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Codice:

International Consensus on Cardiopulmonary Resuscitation.

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