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Environmental Health Sciences

Head
Raffaella
Giavazzi
Dipartimento di Ricerca Ambiente e Salute
raffaella.giavazzi@marionegri.it
Staff
Ivana
Garimoldi
Assistant
Dipartimento di Ricerca Ambiente e Salute
ivana.garimoldi@marionegri.it

The Department of Environment and Health Sciences aims to identify and prevent the negative effect of environmental factors on health.

In particular,it aims to verify the exposure of the population to chemical substances and to assess its risk using in silico and in vitro toxicity studies, analyticalt echniques of mass spectrometry and epidemiology. Furthermore, the effects of drugs diffused in the environment and the consumption of drugs of abuse are also analyzed, through their identification and their measurement in urban wastewater.


ObJECTIVES

  • Identify and measure environmental factors to prevent their impact on health. Among main risk factors causing the development of chronic diseases, such as cardiovascular diseases, diabetes and obesity, we find exposure to tobacco smoke, chemicals, alcohol and specific nutrients
  • Study molecular mechanisms which cause human diseases through the identification of proteome and metabolome alterations, induced by pathological states
  • Development of in silico and in vitro models for the toxicological and ecotoxicological risk assessment of chemical substances.
  • Perform neurotoxicity studies about environmental pollutants and substances which could interfere with endocrine system in in vitro models, based on the differentiation of induced Pluripotent Stem cells (iPS) of human origin towards a neuronal phenotype.
  • Development of new applications of the "wastewater-based epidemiology", a methodology that allows to study the consumption of drugs of abuse, nicotine, alcohol, drugs and specific metabolic markers, indicators of the population health status, measuring them directly in urban wastewater.
  • Development of advanced techniques of mass spectrometry (imaging) to study anticancer drugs penetration into tumor xenografts.

METHODOLOGICAL APPROACHES

  • Surveys representing of the Italian and European adult population
  • Case-control studies to analyze the association between certain factors and the risk of selected chronic diseases, including tinnitus
  • Prospective studies about new generation tobacco products
  • Systematic reviews of the literature
  • Proteomics studies based on the combination of biochemical techniques, mass spectrometry and bioinformatics tools
  • Development of in vitro models of neural and glial cells, derived from iPS of human origin
  • Evaluation of ecotoxicological risk of pesticides
  • Extraction and purification techniques and chemical analysis of biological samples and aqueous matrices
  • Mass spectrometry techniques for liquid chromatography (tandem instrumentation with triple quadrupoles, high resolution instruments Orbitrap, Q-TOF, Q Exactive)
  • Models for the assessment of pollutants exposure and for dose-effect relationships studies
  • Multivariate statistics techniques for identifying the origin of pollutants
  • Systematic literature reviews and meta-analytical techniques for assessing the quality of scientific evidence
  • Methods for develop a list of priority of contaminants
  • Development of in silico models for the toxicological and ecotoxicological risk assessment of chemical substances
  • Development of instrumental approaches for a rapid and objective classification of tissues
  • Development of MS imaging techniques for quantitative studies of drug/metabolite distribution in biological tissues
  • Development, application and integration of different types of omics- data (proteomics,metabolomics) as a multiscale approach, which offers an integrated view of the functional state of a cell or of a pathological state in humans
Results
  • Elaboration of a new method which measure the consumption of drugs and chemicals by the population through the urban wastewater analysis, method now used internationally
  • Definition of the relationship between air pollution and the use of bronchodilator drugs
  • Development of algorithms used to predict the toxicity of chemical compounds used today by the main regulatory authorities
Current projects

Welfare regionale lombardo a tutela degli anziani e dei pazienti cronici: impatto dell’emergenza COVID-19

Sponsor: Regione Lombardia

Research area: Covid-19

UNITI - Unification of treatments and Interventions for Tinnitus patients

Sponsor: Commissione Europea

Research area: Tinnitus

Forme AvaNzate di Gestione dei fanghi di depurazione in un Hub Innovativo lombardo (FANGHI)

Sponsor: Regione Lombardia

Research area: Health impact assessment

Progetti di Rete IRCCS - Rete IRCCS di Neuroscienze e Neuroriabilitazione - RBD-BIO-RIN: Studio multicentrico per l’individuazione di possibili BIOmarkers diagnostici e/o di progressione e/o di outcome per il disordine comportamentale in sonno REM (RBD)

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Sleep disturbances, biomarkers neurological diseases



LIFE VERMEER - Integrating VEGA, toxRead, MERLIN-Expo, and ERICA in a platform for risk assessment and substitution of risky substance

Sponsor: Commissione Europea - LIFE

Research area: Computational toxicology

JATC - Joint Action on Tobacco Control

Sponsor: Commissione Europea - DG Salute

Research area: Tobacco control

LIFE CONCERT REACH - Concerting experimental data and in silico models for REACH

Spnsor: Commissione Europea - LIFE

Research area: Computational toxicology

ERANET - GENDER-NET JTC - 2018 - TIGER - The combined role of genetic and environmental risk factors in the gender-specific development of severe tinnitus

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Tinnitus

OBERON - An integrative strategy of testing systems for identification of endocrine disruptors

Sponsor: Commissione Europea

Research area: Endocrine disruptors

Ricerca Finalizzata - RF-2018-12367150 - Development of a new diagnostic tool based on tumor-associated macrophages to refine the prognosis of patients undergoing hepatic resection for colorectal liver metastases: a prospective study

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Lung cancer

EuSeMe - Europe-wide Sewage analysis to Monitor Emerging drug problems

Sponsor: Commissione Europea - DG Home

Research area: Monitoring the use of drugs and psychoactive substances

EU-ToxRisk - An Integrated European "Flagship" Programme Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st century

Sponsor: Commissione Europea

Research area:  Toxicology

ESIT - European School for Interdisciplinary Tinnitus Research

Sponsor: Commissione Europea - MSCA-ITN

Research area: Tinnitus

in3 - An Integrated Interdisciplinary approach to animal-free nanomaterial and chemical assessment

Sponsor: Commissione Europea - MSCA-ITN

Research area: Toxicology

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Head
Raffaella
Giavazzi
Dipartimento di Ricerca Ambiente e Salute
raffaella.giavazzi@marionegri.it
Staff
Ivana
Garimoldi
Assistant
Dipartimento di Ricerca Ambiente e Salute
ivana.garimoldi@marionegri.it
Pagina Italiano