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Neuroscience

Head
Gianluigi
Forloni
Head of Department
Dipartimento di Ricerca Neuroscienze
gianluigi.forloni@marionegri.it
Staff
Cristina
Masini
Assistant
Dipartimento di Ricerca Neuroscienze
cristina.masini@marionegri.it

The Department of Neuroscience studies neurological and psychiatric diseases, evaluating biological bases, some clinical aspects and the quality of health services. Furthermore, it aims to understand the causes, describe the symptoms and identify therapeutic strategies able to attenuate or arrest the clinical course.


ObJECTIVES

  • Study the most common neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, or even rarer such as prion diseases or amyotrophic lateral sclerosis (SLA). Investigate the underlying pathogenetic mechanisms, using in vivo and in vitro models, up to clinical and epidemiological research
  • Study neurological diseases such as epilepsy, cranial and spinal trauma, brain stroke, autism, and drugs of abuse
  • Develop therapeutic approaches starting from experimental models, and then translate them at the clinical level
  • Study aging to identify possible risk factors and benefits in developing dementia, paying specific attention to genetic aspects
  • Evaluate the quality of services and the impact of geriatric polypharmacy aimed at developing more appropriate therapeutic protocols
  • Identify biomarkers in the different neurological diseases, able to monitor its progress, to improve the diagnostic accuracy and to evaluate the therapeutic impact
  • Identify and characterize classical and innovative biomarkers in plasma, exosomes and CSF. All these elements combined with genetic investigations allow the development of risk profiles useful in neurological patients selection

METHODOLOGICAL APPROACHES

  • Use of experimental models, developed and characterized in vivo, able to replicate some of the biological phenomena underlying various neurological pathologies
  • Behavioral, histopathological and biochemical analysis of the models studied in order to develop and evaluate possible therapeutic approaches
  • Use of biomaterials and nanotechnologies correlated to drug release, cell treatments and diagnostic applications
  • Morphological analysis with different microscopic and image techniques, MRI, confocal microscopy, multifoton and super-resolution microscopy
  • Use of neuronal, mixed glial and organo typic cell cultures, in 3D through morphological, biochemical and electrophysiological analyzes
  • Perform phase I-IV clinical studies, in particular those concerning dementia, SLA, epilepsy and head trauma
  • Perform epidemiological studies using geriatric cohort, which includes several groups of centenarians
  • Geriatric analysis of the quality of services and of protocols for polypharmacy, within national and international networks
  • Use of cellular therapies both in experimental and clinical contexts
Results
  • Discovery of the neuro-protective effect of some drugs during stroke
  • Identification of new strategies for the treatment of epilepsy
  • Development of new therapeutic strategies for Alzheimer's disease

Current projects

EPITARGET - Targets and biomarkers for epileptogenesis

Sponsor: Commissione Europea

Research area: Epilepsy


BBDiag - Blood Biomarker-based Diagnostic Tools for Early-stage Alzheimer's Disease

Sponsor: Commissione Europea - MSCA-ITN

Reasearch Area: Alzheimer disease

ENTRAIN - ENdoThelial macRophage Alliance In Neuroinflammation

Sponsor: Commissione Europea - MSCA-ITN

Reasearch Area: Neuroinflammation


In vivo and in vitro imaging of pro-thrombotic events in brain ischemic injury: focus on mannose-binding lectin and beta2 glycoprotein I

Sponsor: Fondazione Cariplo

Reasearch Area: Neuroinflammation

Association between frailty trajectories and biological markers of aging. FrailBioTrack

Sponsor: Fondazione Cariplo

Reasearch Area: Neurodegenerative diseases linked to ageing

Study of the molecular mechanisms underlying the sex difference in muscle wasting induced by cancer

Sponsor: Associazione Italiana per la Ricerca sul Cancro (AIRC)

Reasearch Area: Cachexia

Fatal familial insomnia: preventive treatment with doxycycline of at risk individuals

Sponsor: Fondazione TELETHON

Reasearch Area: Familiar fatal insomnia, Prion diseases

New exploitation of a porphyrin: characterisation of the mechanism of action and preclinical studies in mouse models of genetic prion disease

Sponsor: Fondazione TELETHON

Reasearch Area: Prion diseases

Role of the Coiled-coil structure of the Huntington protein in the intercellular propagation of polyQ aggregates and in the progression of the disease

Sponsor: Fondazione TELETHON

Reasearch Area: Neurodegenerative diseases

Assessing safety and efficacy of Vortioxetine versus SSRIs in elderly patients with depression: a pragmatic, multicenter, open-label, parallel-group, superiority, randomized trial (Version 3, 05/12/2016). VESPA study: Vortioxetine in the Elderly vs. SSRIs: a Pragmatic Assessment

Sponsor: Agenzia Italiana del Farmaco AIFA

Reasearch Area: Ageing diseases

Inhibitor development in previously untreated patients with severe haemophilia A, an international, multicentre, prospective, controlled, randomized, open label, clinical trial SIPPET 2

Sponsor: Agenzia Italiana del Farmaco AIFA

Reasearch Area: Rare diseases

Ricerca Finalizzata - GR-2013-02355028 - New mTOR inhibitors development and study of their effects on the central nervous system (mTORNEU)

Sponsor Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Epilepsy

Ricerca Finalizzata - RF-2016-02362950 - Therapeutic efficacy test of a new anti-prion compound using in vivo and in vitro models of human prion disease

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Prion diseases

Ricerca Finalizzata - GR-2016-02361904 - A step forward to traumatic brain injury therapy: preclinical effectiveness of mesenchymal cell derivatives for the development of a cell-free therapeutic strategy

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Cranic trauma

Ricerca Finalizzata - RF-2016-02361941 - Human and animal studies: a novel strategy against Alzheimer synaptic dysfunction

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Alzheimer's disease

Ricerca Finalizzata - RF-2016-02364918 - An integrated platform for molecular studies and clinical trials in myelodysplastic syndromes

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Myelodysplastic syndrome

ERANET - E-Rare JTC - 2014 - CHAPRION - Pharmacological chaperones for genetic prion diseases

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Prion diseases

ERANET - NEURON JTC - 2016 - LEAP - New therapeutic strategies in the treatment of traumatic brain injury by targeting the LEctin Activation Pathway of complement

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Cranic trauma

ERANET - NEURON JTC - 2016 - ICON-TBI - International Collaboration On Neuroinflammation in Traumatic Brain Injury

Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Cranic trauma

ERANET - JPND JTC - 2017 - RNA-NEURO - Systems Analysis of novel small non-coding RNA in neuronal stress responses: towards novel biomarkers and therapeutics for neurodegenerative disorders

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Neurodegenerative diseases

Progetti di Rete IRCCS - Rete Cardiovascolare - Validation of a peripheral biomarker of atherosclerotic lesions

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Ischemia

Progetti di Rete IRCCS - Rete IRCCS di Neuroscienze e Neuroriabilitazione - Development and implementation of advanced diagnostics and tele-rehabilitation protocols in the field of neurological pathologies

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Neurological diseases, Magnetic Resonance Imaging

Progetti di Rete IRCCS - Rete IRCCS per l'Invecchiamento - Roadmap of investigation on ageing and age-related diseases

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Ageing diseases

Translating molecular mechanisms into Amyotrophic lateral sclerosis risk and patient's well-being - TRANS-ALS

Sponsor: FRRB - Fondazione Regionale per la Ricerca Biomedica - Regione Lombardia

Reasearch Area: Lateral amyotrophic sclerosis

Pharmacoepidemiology (EPIFARM - Epidemiologia del Farmaco)

Sponsor: Regione Lombardia

Reasearch Area: Cardiovascular, Diabetes, Geriatrics, Pediatrics

Study of JNK role in the regulation of early synaptic alterations and irreversible progressive neuronal degeneration in RETT syndrome

Sponsor: AIRETT - Associazione Italiana Rett

Reasearch Area: Rett syndrome

An infantile rat model of epilepsy for testing disease-modifying drugs for Ring14 syndrome

Sponsor: Ring14 International Onlus

Reasearch Area: RING14 syndrome

Potential therapeutic approach for synaptic deficit in Angelman syndrome: the JNK inhibitor peptide

Sponsor: Angelman Syndrome Alliance

Reasearch Area: Angelman syndrome

Prion-like tauopathy in post-traumatic Alzheimer's disease

Sponsor: Alzheimer's Association

Reasearch Area: Alzheimer disease

The effects of RNS60 on ALS biomarkers

Sponsor: The ALS Association - ALS Finding a Cure

Reasearch Area: Lateral amyotrophic sclerosis

Kv channel inhibition as a novel glia-targeted therapeutic strategy in epilepsy

Sponsor: Associazione Italiana contro l'Epilessia - Fondazione Italiana per la Ricerca sull'Epilessia (AICE-FIRE)

Reasearch Area: Epilepsy

Prospective register (REPOSI) on multimorbidity and polypharmacy in older patients hospitalized in internal medicine and geriatric wards in Italy

Sponsor: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Reasearch Area: Elderly polytherapy

Nanoparticle-mediated brain delivery of a tetracationic porphyrin with potent anti-prion activities

Sponsor: CJD Foundation

Reasearch Area: Prion diseases

Generation and application of areporter mouse to follow in vivo skeletal muscle wasting, a lethal conditionaccompanying several chronic diseases

Sponsor: Fondazione CARIPLO

Research area: Cachessia

Other Dipartments: Ambiente e Salute

Ricerca Finalizzata -GR-2016-02361198 - Evaluation of the effectiveness of a low-cost informativeintervention to improve the appropriate prescription of proton pump inhibitorsin older people in primary care: a cluster-randomized controlled study

Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità

Research area: INTERVENTO EDUCATIVO RIVOLTO A MEDICI DI MEDICINA GENERALE

Ricerca Finalizzata -RF-2016-02363902 - Efficacy and tolerability of low vs. standard daily doses ofantiepileptic drugs in newly diagnosed, previously untreated epilepsy. Amulticenter, randomized, single-blind, parallel group trial - STANDLOW

Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità

Research area: Epilessia

Prion-like tauopathy inpost-traumatic Alzheimer's disease

Sponsor: Alzheimer's Association

Research area: Malattia di Alzheimer

ERANET - JPND JTC - 2017 - RNA-NEURO- Systems Analysis of novel small non-coding RNA in neuronal stress responses:towards novel biomarkers and therapeutics for neurodegenerative disorders

Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità

Research area: Malattie neurodegenerative

Ricerca Finalizzata -SG-2018-12366226 - Modulating theATP - purinoreceptor P2X7 signaling in theskeletal muscles of SOD1G93A mice as a ground-breaking strategy to hinder theprogression of Amyotrophic Laterla Sclerosis

Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità

Research area: Amyotrophic Lateral Sclerosis (ALS)

Combinatorial biosignatures ofnetwork dysfunction to predict post-traumatic epilepsy: clinical translationfrom a robust mouse model

Sponsor: Department of Defense USA

Research area: Trauma cranico, epilessia, biomarcatori

ERANET - ERANet Neuron JTC - 2019 -EBio2 - Early mechanistic BIOmarkers for late Epilepsy and long-term BrainInjury Outcome

Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità

Research area: Epilessia

ERANET - ERANet Neuron JTC - 2019 -Stroke risk prediction in atherosclerosis measuring circulating complementsystem proteins (STATEMENT)

Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità

Research area: Ischemia

MUSALS-AChR - Studying acetylcholinereceptors and muscle regeneration in ALS to develop prognostic markers andpotential therapies hampering disease progression

Sponsor: AriSLA - Fondazione Italiana di Ricerca per la SLA

Research area: Sclerosi Laterale Amiotrofica

Progetti di Rete IRCCS - ReteCardiologica - Strategie integrate per lo studio dei determinanti cellulari egenomici della placca ateromasica - WP3: Ruolo della via lectinica delcomplemento nelle lesioni aterosclerotiche vulnerabili

Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità

Research area: Ischemia

Progetti di Rete IRCCS - Rete IRCCSper l'Invecchiamento -  Implementazione della RoadMap nella Ricercasull'Aging (IRMA)

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Malattie legate all'invecchiamento

Progetti di Rete IRCCS - Rete IRCCSdi Neuroscienze e Neuroriabilitazione - Rete di Neuroimaging avanzato-fase IV:laboratorio virtuale di neuroimmagini verso una medicina personalizzata/diprecisione

Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità

Research area: Malattie neurologiche, Imaging a risonanza magnetica

Progetti di Rete IRCCS - Rete IRCCSdi Neuroscienze e Neuroriabilitazione - Sviluppo ed armonizzazione delleProcedure Standard Operative (SOP) per l’accesso alla condivisione di datiall’interno della piattaforma di genomica della Rete IRCCS delle Neuroscienze

Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità

Research area: Malattie neurologiche, genomica

Progetti di Rete IRCCS - Rete IRCCSdi Neuroscienze e Neuroriabilitazione - Caratterizzazione clinica e molecolaree correlazioni genotipo-fenotipo di pazienti affetti da malattia di Parkinson:sviluppo di protocolli innovativi (ParkNet). Fase 2

Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità

Research area: Malattie neurologiche, Malattia di Parkinson

Progetti di Rete IRCCS - Rete IRCCSdi Neuroscienze e Neuroriabilitazione - Approcci innovativi perl’identificazione e la validazione di biomarcatori nell’ambito delle malattieneurodegenerative

Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità

Research area: Malattie neurodegenerative

Progetti di Rete IRCCS - Rete IRCCSdi Neuroscienze e Neuroriabilitazione - Armonizzazione e aggiornamento delleprocedure di valutazione cognitiva/comportamentale in neurologia

Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità

Research area: Malattie neurologiche

Evaluating prion vaccines intransgenic mouse models of familial prion diseases

Sponsor: CJD Foundation - USA

Research area: Malattie da prioni

 

Identifying proteomic, metabolomic and microRNA biomarkers signifying spontaneous post-traumatic epilepsy in a CD1 mouse model of traumatic brain injury

Sponsor: CURE (Citizen United for Research in Epilepsy)

Research area: Trauma cranico, epilessia, biomarcatori

INnovazione, nuovi modelli TEcnologici e Reti per curare la SLA

Sponsor: Regione Lombardia

Research area: Sclerosi Laterale Amiotrofica

A gene  therapy approach for Marinesco-Sjogren syndrome

Sponsor: National Ataxia Foundation (NAF)

Research area: Sindrome  Marinesco-Sjogren

Role of  T-cells in injury evolution after aneurysmal subarachnoid hemorrhage.  Clinical and experimental study

Sponsor: Fondazione  Cariplo

Research area: Neuroscienze

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Head
Gianluigi
Forloni
Head of Department
Dipartimento di Ricerca Neuroscienze
gianluigi.forloni@marionegri.it
Staff
Cristina
Masini
Assistant
Dipartimento di Ricerca Neuroscienze
cristina.masini@marionegri.it
Pagina Italiano