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Neuroscience

Head
Gianluigi
Forloni
Head of Department
Neuroscienze
gianluigi.forloni@marionegri.it
Staff
Cristina
Masini
Assistant
Neuroscienze
cristina.masini@marionegri.it

The Department of Neuroscience studies neurological and psychiatric diseases, evaluating biological bases, some clinical aspects and the quality of health services. Furthermore, it aims to understand the causes, describe the symptoms and identify therapeutic strategies able to attenuate or arrest the clinical course.


ObJECTIVES

  • Study the most common neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, or even rarer such as prion diseases or amyotrophic lateral sclerosis (SLA). Investigate the underlying pathogenetic mechanisms, using in vivo and in vitro models, up to clinical and epidemiological research
  • Study neurological diseases such as epilepsy, cranial and spinal trauma, brain stroke, autism, and drugs of abuse
  • Develop therapeutic approaches starting from experimental models, and then translate them at the clinical level
  • Study aging to identify possible risk factors and benefits in developing dementia, paying specific attention to genetic aspects
  • Evaluate the quality of services and the impact of geriatric polypharmacy aimed at developing more appropriate therapeutic protocols
  • Identify biomarkers in the different neurological diseases, able to monitor its progress, to improve the diagnostic accuracy and to evaluate the therapeutic impact
  • Identify and characterize classical and innovative biomarkers in plasma, exosomes and CSF. All these elements combined with genetic investigations allow the development of risk profiles useful in neurological patients selection

METHODOLOGICAL APPROACHES

  • Use of experimental models, developed and characterized in vivo, able to replicate some of the biological phenomena underlying various neurological pathologies
  • Behavioral, histopathological and biochemical analysis of the models studied in order to develop and evaluate possible therapeutic approaches
  • Use of biomaterials and nanotechnologies correlated to drug release, cell treatments and diagnostic applications
  • Morphological analysis with different microscopic and image techniques, MRI, confocal microscopy, multifoton and super-resolution microscopy
  • Use of neuronal, mixed glial and organo typic cell cultures, in 3D through morphological, biochemical and electrophysiological analyzes
  • Perform phase I-IV clinical studies, in particular those concerning dementia, SLA, epilepsy and head trauma
  • Perform epidemiological studies using geriatric cohort, which includes several groups of centenarians
  • Geriatric analysis of the quality of services and of protocols for polypharmacy, within national and international networks
  • Use of cellular therapies both in experimental and clinical contexts

Results

  • Discovery of the neuro-protective effect of some drugs during stroke
  • Identification of new strategies for the treatment of epilepsy
  • Development of new therapeutic strategies for Alzheimer's disease

Current projects

EPITARGET - Targets and biomarkers for epileptogenesis

Sponsor: Commissione Europea

Research area: Epilepsy


BBDiag - Blood Biomarker-based Diagnostic Tools for Early-stage Alzheimer's Disease

Sponsor: Commissione Europea - MSCA-ITN

Reasearch Area: Alzheimer disease

ENTRAIN - ENdoThelial macRophage Alliance In Neuroinflammation

Sponsor: Commissione Europea - MSCA-ITN

Reasearch Area: Neuroinflammation


In vivo and in vitro imaging of pro-thrombotic events in brain ischemic injury: focus on mannose-binding lectin and beta2 glycoprotein I

Sponsor: Fondazione Cariplo

Reasearch Area: Neuroinflammation

Aging of hematopoietic stem cells - molecular architecture of marrow dysplasia and clinical contribution of ineffective hematopoiesis to frailty in the elderly

Sponsor: Fondazione Cariplo

Reasearch Area: Neurodegenerative diseases linked to ageing

Association between frailty trajectories and biological markers of aging. FrailBioTrack

Sponsor: Fondazione Cariplo

Reasearch Area: Neurodegenerative diseases linked to ageing

Study of the molecular mechanisms underlying the sex difference in muscle wasting induced by cancer

Sponsor: Associazione Italiana per la Ricerca sul Cancro (AIRC)

Reasearch Area: Cachexia

Fatal familial insomnia: preventive treatment with doxycycline of at risk individuals

Sponsor: Fondazione TELETHON

Reasearch Area: Familiar fatal insomnia, Prion diseases

New exploitation of a porphyrin: characterisation of the mechanism of action and preclinical studies in mouse models of genetic prion disease

Sponsor: Fondazione TELETHON

Reasearch Area: Prion diseases

Role of the Coiled-coil structure of the Huntington protein in the intercellular propagation of polyQ aggregates and in the progression of the disease

Sponsor: Fondazione TELETHON

Reasearch Area: Neurodegenerative diseases

Assessing safety and efficacy of Vortioxetine versus SSRIs in elderly patients with depression: a pragmatic, multicenter, open-label, parallel-group, superiority, randomized trial (Version 3, 05/12/2016). VESPA study: Vortioxetine in the Elderly vs. SSRIs: a Pragmatic Assessment

Sponsor: Agenzia Italiana del Farmaco AIFA

Reasearch Area: Ageing diseases

Inhibitor development in previously untreated patients with severe haemophilia A, an international, multicentre, prospective, controlled, randomized, open label, clinical trial SIPPET 2

Sponsor: Agenzia Italiana del Farmaco AIFA

Reasearch Area: Rare diseases

Ricerca Finalizzata - GR-2013-02355028 - New mTOR inhibitors development and study of their effects on the central nervous system (mTORNEU)

Sponsor Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Epilepsy

Ricerca Finalizzata - GR-2013-02358677 - RApid versus SLOw Withdrawal of antiepileptic monotherapy in two-year seizure-free adult patients with epilepsy (RASLOW Study): a pragmatic multicentre, prospective, randomized, controlled study

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Epilepsy

Ricerca Finalizzata - RF-2016-02362950 - Therapeutic efficacy test of a new anti-prion compound using in vivo and in vitro models of human prion disease

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Prion diseases

Ricerca Finalizzata - GR-2016-02361904 - A step forward to traumatic brain injury therapy: preclinical effectiveness of mesenchymal cell derivatives for the development of a cell-free therapeutic strategy

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Cranic trauma

Ricerca Finalizzata - RF-2016-02361941 - Human and animal studies: a novel strategy against Alzheimer synaptic dysfunction

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Alzheimer's disease

Ricerca Finalizzata - RF-2016-02364918 - An integrated platform for molecular studies and clinical trials in myelodysplastic syndromes

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Myelodysplastic syndrome

ERANET - E-Rare JTC - 2014 - CHAPRION - Pharmacological chaperones for genetic prion diseases

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Prion diseases

ERANET - NEURON JTC - 2016 - LEAP - New therapeutic strategies in the treatment of traumatic brain injury by targeting the LEctin Activation Pathway of complement

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Cranic trauma

ERANET - NEURON JTC - 2016 - ICON-TBI - International Collaboration On Neuroinflammation in Traumatic Brain Injury

Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Cranic trauma

ERANET - JPND JTC - 2017 - RNA-NEURO - Systems Analysis of novel small non-coding RNA in neuronal stress responses: towards novel biomarkers and therapeutics for neurodegenerative disorders

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Neurodegenerative diseases

Progetti di Rete IRCCS - Rete Cardiovascolare - Validation of a peripheral biomarker of atherosclerotic lesions

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Ischemia

Progetti di Rete IRCCS - Rete IRCCS di Neuroscienze e Neuroriabilitazione - Development and implementation of advanced diagnostics and tele-rehabilitation protocols in the field of neurological pathologies

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Neurological diseases, Magnetic Resonance Imaging

Progetti di Rete IRCCS - Rete IRCCS per l'Invecchiamento - Roadmap of investigation on ageing and age-related diseases

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Reasearch Area: Ageing diseases

Translating molecular mechanisms into Amyotrophic lateral sclerosis risk and patient's well-being - TRANS-ALS

Sponsor: FRRB - Fondazione Regionale per la Ricerca Biomedica - Regione Lombardia

Reasearch Area: Lateral amyotrophic sclerosis

Pharmacoepidemiology (EPIFARM - Epidemiologia del Farmaco)

Sponsor: Regione Lombardia

Reasearch Area: Cardiovascular, Diabetes, Geriatrics, Pediatrics

Study of JNK role in the regulation of early synaptic alterations and irreversible progressive neuronal degeneration in RETT syndrome

Sponsor: AIRETT - Associazione Italiana Rett

Reasearch Area: Rett syndrome

An infantile rat model of epilepsy for testing disease-modifying drugs for Ring14 syndrome

Sponsor: Ring14 International Onlus

Reasearch Area: RING14 syndrome

Potential therapeutic approach for synaptic deficit in Angelman syndrome: the JNK inhibitor peptide

Sponsor: Angelman Syndrome Alliance

Reasearch Area: Angelman syndrome

Role of Sumoylation in the aggregation and toxicity of TAU

Sponsor: Alzheimer's Association

Reasearch Area: Alzheimer disease

Prion-like tauopathy in post-traumatic Alzheimer's disease

Sponsor: Alzheimer's Association

Reasearch Area: Alzheimer disease

The effects of RNS60 on ALS biomarkers

Sponsor: The ALS Association - ALS Finding a Cure

Reasearch Area: Lateral amyotrophic sclerosis

A prospective registry on critical outcomes related to polypharmacy in older patients with severe/moderate haemophilia

Sponsor: Fondazione Luigi Villa / Bayer Hemophilia Awards Program

Reasearch Area: Elderly polytherapy

Mapp the drug: a pharmacovigilance system of extended half-life treatment products for haemophilia

Sponsor: Fondazione Luigi Villa / Bayer Hemophilia Awards Program

Reasearch Area: Pharmacovigilance

Kv channel inhibition as a novel glia-targeted therapeutic strategy in epilepsy

Sponsor: Associazione Italiana contro l'Epilessia - Fondazione Italiana per la Ricerca sull'Epilessia (AICE-FIRE)

Reasearch Area: Epilepsy

Clinical and biological correlates of resistant depression and related phenotypes (TRD3)

Sponsor: Group for the Study of Resistant Depression (GSRD)

Reasearch Area: Depression

Prospective register (REPOSI) on multimorbidity and polypharmacy in older patients hospitalized in internal medicine and geriatric wards in Italy

Sponsor: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Reasearch Area: Elderly polytherapy

Nanoparticle-mediated brain delivery of a tetracationic porphyrin with potent anti-prion activities

Sponsor: CJD Foundation

Reasearch Area: Prion diseases

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Head
Gianluigi
Forloni
Head of Department
Neuroscienze
gianluigi.forloni@marionegri.it
Staff
Cristina
Masini
Assistant
Neuroscienze
cristina.masini@marionegri.it
Pagina Italiano