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Biomedical Engineering

Head
Norberto
Perico
Head of Laboratory
Dipartimento di Ricerca Bioingegneria
norberto.perico@marionegri.it
Staff
Silvia
Nolli
Dipartimento di Ricerca Bioingegneria
silvia.nolli@marionegri.it
Senior Advisor
No items found.

The Departmentof Biomedical Engineering conducts studies at the experimental and clinical levels. Within the Department, pathophysiological processes are studied using radiodiagnostic imaging and engineering techniques, which make possible the quantitative in vivo analysis of biological structures and processes.

ObJECTIVES

  • Study the mechanisms involved in the progression of chronic nephropathy
  • Study the mechanobiology of vascular cells
  • Study morphological and hemodynamic alterations in different vascular districts and the role of hemodynamics in the development of vascular damage
  • Study the molecular mechanisms that determine the development of stenosis in the vascular access
  • Study the relationship between sound alteration and vascular damage, vascular wall vibrations and vascular damage
  • Study of the cytotoxicity of micro and nano-particulate matter from brake systems
  • Develop segmentation and quantification techniques of anatomical structures and pathological lesions on diagnostic images in response to specific clinical needs
  • Identify and validate new imaging biomarkers
  • Conduct clinical validation of new non-invasive imaging techniques for the study of organ physiology and pathophysiology
  • Develop and validate information systems for managing clinical data and images generated in controlled clinical trials and in clinical practice

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METHODOLOGICAL APPROACHES

  • Diagnostic and histological image processing using analytical techniques and artificial intelligence
  • Computational fluid dynamic simulations
  • Experimental and clinical measurements of physico-chemical parameter
  • Cell culture techniques
  • Microscopy and computed microtomography techniques
  • Information systems for controlled clinical trials and clinical practice

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Results
  • Development and validation of a multiparametric magnetic resonance imaging protocol for kidney disease
  • Identification of the role of hemodynamic conditions in the development of vascular damag
  • Development of new imaging techniques for tissue sample analysis
  • Development of a theoretical model of blood circulation to improve vascular surgical planning
  • Development of artificial intelligence algorithms for medical image analysis
  • New indicators for the characterisation of human pathophysiology
  • Development of information systems for clinical data management

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Current projects

‍Renal MRI standardization to improve personalised management of CKD patients (RESPECT)‍‍

Sponsor: Italian Ministry of Health

Research area: Medical imaging/Chronic nephropaty

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Unraveling the role of wall vibrations in the formation of vascular stenosis (TEST YOUR IDEA)

Sponsor: Fondazione Terzi-Albini

Research area: Mechanobiology of blood vessels

AdvaNced Technology for Human centEred Medicine (ANTHEM)

Sponsor: Italian ministry for Universities and Research

Research area: Medical Imaging

AI-based methods to improve stratification of patients affected by Polycystic Kidney Disease using multi-parametric MRI (AI4PKD)

Sponsor:  Italian ministry for Universities and Research

Research area: Polycystic kidney disease

Toxicological characterization and environmental impact of particulate matter from brake system

Sponsor: BREMBO

Research area: Toxicology

Personalised SGLT2i treatment in diabetic kidney disease supported by multiparametric renal magnetic resonance imaging (PERSONALISE-DKD)

Sponsor: Italian Ministry of Health

Research area: Medical imaging/Diabetic nephropathy

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Head
Norberto
Perico
Head of Laboratory
Dipartimento di Ricerca Bioingegneria
norberto.perico@marionegri.it
Staff
Silvia
Nolli
Dipartimento di Ricerca Bioingegneria
silvia.nolli@marionegri.it
Senior Advisor
No items found.

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