The goal of the Department of Oncology is to offer therapies for the treatment of tumors more effective through studies that investigate molecular, biological and pharmacological aspects.
The final goal is to obtain clinical applications which could ameliorate survival and quality of life of oncological patients.
The projects carried out by the Department concern different types of tumors, but the majority of preclinical and clinical studies focus on gynecological tumors, sarcomas, thoracic tumors (lung, mesotheliomasand thymomas) and pancreatic tumors.
Development of new therapies for tumors that metastatize the bone
Sponsor: Fondazione Beppe e Nuccy Angiolini
Research area: Bone tumors
A multicenter phase III randomised study with second-line chemotherapy plus or minus bevacizumab in patients with platinum-sensitive epithelial ovarian cancer recurrence after a bevacizumab/chemotherapy first line
Sponsor: Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
Reasearch area: Ovarian tumors
ERANET - Euronanomed III JTC - 2018 - CONCORD - Cationic Gold nanoparticles mediated mRNA cytoplasmatictargeted delivery for production of CAR-T lymphocytes for Chronic Lymphoid Leukemia immunotherapy
Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità
Reasearch area: Leukemia, nanoparticles
Sponsor: Fondazione Cariplo
Reasearch area: Biomedical
Ricerca Finalizzata - GR-2016-02361849 - Liquid biopsies as predictors of response in advanced Non-Small Cell Lung Cancer patients receiving immune checkpoint inhibitors
Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità
Reasearch area: Lung cancer
Improving treatment strategies in thymic epithelial tumors: a TYME collaborative effort
Sponsor: Agenzia Italiana del Farmaco AIFA
Research area: Timomas
EXemestane in Progesterone and/or Estrogen receptor positive epithelial ovarian cancer. A Randomized phase III Trial, EXPERT
Sponsor: Agenzia Italiana del Farmaco AIFA
Research area: Ovarian cancer
Open-label, randomized controlled trial comparing tocilizumab to anti-TNF treatment and discovery of biomarkers for treatment selection in rheumatoid arthritis patients with inadequate response to a first anti-TNF (RAFTING)
Sponsor: Agenzia Italiana del Farmaco AIFA
Research area: Rheumatoid arthritis
Exploiting LKB1 vulnerability by selective metabolic treatments in advanced Non-Small Cell Lung Cancer
Sponsor: Associazione Italiana per la Ricerca sul Cancro (AIRC)
Research area: Lung cancer
Thrombospondins at the interface between tumor cells and the microenvironment, from insight to therapeutic approaches
Sponsor: Associazione Italiana per la Ricerca sul Cancro (AIRC)
Research area: Tumoral microenvironment
Causative roles of metabolic reprogramming and DNA repair in cisplatin resistance in ovarian carcinoma
Sponsor: Associazione Italiana per la Ricerca sul Cancro (AIRC)
Research area: Ovarian cancers
dISCOVER - Integrated Signature Classifier to assess prognosis in stage I epithelial OVarian cancEr
Sponsor: Associazione Italiana per la Ricerca sul Cancro (AIRC)
Research area: Ovarian cancers
Approaches to establish threedimensional models to identify new vulnerabilities in undruggable LKB1 mutatedNSCLCSponsor: Fondazione Cariplo
Sponsor: Fondazione Cariplo
Research area: Tumore del Polmone
Identification of metabolicalterations promoting ovarian cancer abdominal metastasis induced byangiogenesis inhibitors
Sponsor: Fondazione Cariplo
Research area: Tumore dell'Ovaio
Ricerca Finalizzata -GR-2018-12365661 - Cancer in Heart fAilure: characteriziNg the association witha dual epidemioloGical and Experimental approach (CHANGE study)
Sponsor: Ministero della Salute, DG Ricerca e Innovazione inSanità
Research area: Tumore e insufficienza cardiaca
Development of new therapies fortumors that metastatize the bone
Sponsor: Fondazione Beppe e Nuccy Angiolini
Research area: Tumori ossei
Progetti di ricerca sul tumoredell'ovaio
Sponsor: Fondazione Alessandra Bono Onlus
Research area: Tumore dell'ovaio
Exploit metabolic plasticity toimprove therapeutic efficacy and manage ovarian cancer progression
Sponsor: Associazione Italiana per la Ricerca sul Cancro - AIRC
Research area: Tumore dell'ovaio
Enhancement of trabectedin efficacyand trabectedin-induced adipocytic differentiation in liposarcomas by PPARgagonists
Sponsor: Associazione Italiana per la Ricerca sul Cancro - AIRC
Research area: Sarcomi
Trypsins/MMPs axis in theinteraction of pancreatic cancer with the microenvironment
Sponsor: Associazione Italiana per la Ricerca sul Cancro - AIRC
Research area: Tumore del pancreas
Molecular and clinicalindividualization of adjuvant therapy for stage II and IV colon cancer
Sponsor: Associazione Italiana per la Ricerca sul Cancro - AIRC
Reseaech area: Tumore del colon
Metastasis as mechanodisease
Sponsor: Associazione Italiana per la Ricerca sul Cancro - AIRC 5per mille - Programma Metastatic disease
Research area: Tumore alla mammella