The Department of Acute Brain and Cardiovascular Injury investigates brain and cardiological conditions, including epilepsia, traumatic brain injury, stroke and cardiac arrest aiming at improving the disease course and prognosis.
Brain and vascular damage associated with these conditions leads to severe chronic cognitive and/or motor impairment and/or recurrent epileptic seizures in a high percentage of patients.
Developing therapies for these patients is, therefore, a priority.
The aim of the Department is to develop preclinical models and foster the interaction between laboratory and clinical activities, to:
Functional and structural cerebrovascular alterations in neurological disorders: the role of complement (VASCO)
Ente Finanziatore: Fondazione Regionale per la Ricerca Biomedica, Regione Lombardia
Area: Neuroinfiammazione e ictus ischemico
Blood markers of post-traumatic epilepsy prediction and electrophysiological biomarkers of early PTE detection
Ente Finanziatore: Department of Defense, USA-funded study (W81XWH-15-2-0069
Area: Trauma cranico, epilessia e neuroinfiammazione
Early mechanistic BIOmarkers for late Epilepsy and long-term Brain Injury Outcome
Ente Finanziatore: ERA-NET NEURON (Call for Joint Transnational Research Projects 2019, TRANSLATIONAL BIOMARKERS IN BRAIN DISORDERS)
Area: Epilessia e neuroinfiammazione
Prospective preclinical and clinical studies of gut microbiota, intestinal barrier, and related blood metabolites, following traumatic brain injury for developing prognostic biomarkers of chronic neurological sequelae, and for identifying targets to prevent the progressive evolution of brain injury and the chronic disabilities
Ente Finanziatore: Ministero della Salute - Unione Europea (NextGenerationEU)-2-0069)
Area: Trauma cranico, microbiota
Mesenchymal stromal cells for TBI – clinical trial
Enti Finanziatori: Fondazione regionale per la ricerca (FRRB) e Ministero della Salute Ricerca Finalizzata
Area: neuroprotezione e trauma cranico
Progetti di Rete IRCCS - Rete Cardiologica - Digital strategies in primary cardiovascular prevention in the Italian population (CV PREVITAL)
Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità
Area di Ricerca: Prevenzione cardiovascolare
Mechanisms accounting for brain protection by argon following resuscitation from cardiac arrest
Ente Finanziatore: Laerdal Foundation, Norvegia
Area di Ricerca: Danno cerebrale dopo arresto cardiaco
Improving outcomes in cardiac arrest and cardiopulmonary resuscitation with kynurenine pathway inhibition
Ente Finanziatore: European Society of Anaesthesiology - ESA AISBL, Belgio
Area di Ricerca: Arresto cardiaco
Ricerca Finalizzata - RF-2016-02364318 - Selection of people at low cardiovascular risk: development of an inexpensive pre-screening algorithm using only non-laboratory measures. The SKIM risk study
Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità
Area di Ricerca: Rischio cardiovascolare
Ricerca Finalizzata - RF-2016-02361583 - Efficacy of Albumin Replacement and Balanced Crystalloid Solutions in Septic Shock (the ALBIOSS-BALANCED trial): a 2-by-2 factorial, investigator-initiated, open-label, multicenter, randomized, controlled trial
Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità
Area di Ricerca: Shock Settico
Progetti di Rete IRCCS - Rete Cardiovascolare - Implementation of mobile Health and eHealth approaches for optimal cardiovascular prevention - IMPROVE Study
Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità
Area di Ricerca: Prevenzione cardiovascolare
SECURE - Secondary Prevention of Cardiovascular Disease in the Elderly, a prospective randomized clinical trial comparing a polypill versus standard of care treatment strategies in post MI elderly patients
Ente Finanziatore: Commissione Europea
Area di Ricerca: Malattie Cardiovascolari
ESCAPE-NET - European Sudden Cardiac Arrest network: towards Prevention, Education and NEw Treatment
Ente Finanziatore: Commissione Europea
Area di Ricerca: Malattie Cardiovascolari
Treat_CCM Clinical Trial - A multicenter randomized clinical trial on Propranolol in Cerebral Cavernous Malformation (CCM)
Ente Finanziatore: Agenzia Italiana del Farmaco AIFA
Area di Ricerca: Malattie rare, CCM
The Research Center for Amyotrophic Lateral Sclerosis (ALS Center) brings together the groups that are involved in ALS research from an epidemiological, preclinicaland translational point of view.