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Biochemistry and Molecular Pharmacology

Head
Mario
Salmona
Head of Department
Biochimica e Farmacologia molecolare
mario.salmona@marionegri.it
Staff
Elena
Pozzoli
Assistant
Biochimica e Farmacologia molecolare
elena.pozzoli@marionegri.it

The research of the Department of Biochemistry and Molecular Pharmacology is aimed at the structural and functional study of specific and pharmacologically relevant gene products.

One of the principle goals is the identification of new proteins that could represent targets for drug therapy. Potential drug-protein interactions are studied also at the molecular level, using a wide variety of approaches ranging from studies performed on animal models to computational simulations.


ObJECTIVES

  • Development of efficient pharmacological strategies availing of pharmacological and functional studies (pharmacokinetics/pharmacodynamic), drugs repositioning, peptides therapy, multiomics approaches and machine learning in the study of patient selection, as crucial element for personalized medicine improvment, nanoparticles in nanomedicine and nanodiagnostics, differentiating agents for personalized treatment of breast and stomach cancer, analysis of nuclear receptor as pharmacological target in oncology, analysis of molecular interactions
  • Identification of molecular targets of protein-mediated diseases (genetic diseases and diseases caused by aberrant structure proteins)
  • Identification of protein markers in biological fluids, cells, tissues and extracellular vesicles both in patients and animal models

METHODOLOGICAL APPROACHES

  • Use of in vivo experimental animal models (vertebrates and invertebrates) to study peripheral amyloidosis, neurodegenerative and tumor diseases
  • Use of in vitro experimental models (cell lines, biopsies and pluripotent stem cells) to study peripheral amyloidosis, neurodegenerative and tumor diseases
  • Protein synthesis and purification
  • Use of drug quantification methods in biological matrices
  • Use of methods of interaction between proteins and biomolecules
  • Use of gene sequencing methods and next computational analysis of results
  • Use of "System Biology" approach to collect, integrate and analyze heterogeneous and multi-parameter data

Results

Development of new drugs for the treatment of acute myeloid leukemia

Current projects

ERANET - Euronanomed III JTC - 2019 - CELLUX - CeO2 Nanoparticles-assisted stem cell therapy: an innovative nanopharmaceutical approach to treat retinal degenerative diseases

Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Area di Ricerca: Nanomedicina

Ricerca Finalizzata - RF-2018-12365371 - Ablation of the maladaptive ER stress response restores diaphragm function and insulin resistance in SEPN1-related myopathies

Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Area di Ricerca: Neurologia

Ricerca Finalizzata - RF-2018-12365614 - TDP-43 pathology and Lys-acetylation in circulating lymphomonocytes as biomarkers and therapeutic hints for amyotrophic lateral sclerosis

Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Area di Ricerca: Amyotrophic lateral sclerosis

Altri dipartimenti: Ambiente Salute


Nuclear receptors controlling lipid homeostasis: novel targets for the personalized tratment of breast cancer

Ente Finanziatore: Associazione Italiana per la Ricerca sul Cancro - AIRC

Area di Ricerca: Tumore alla mammella

Verso una definizione dei fattori di rischio per la malattia di Alzheimer

Ente Finanziatore: Fondo di beneficenza - Intesa Sanpaolo S.p.A.

Area di Ricerca: Malattia di Alzheimer

SUMOylation  in Alzheimer's disease and dementia

Ente Finanziatore: BrightFocus Foundation, USA

Area di Ricerca: Malattia di Alzheimer

Altri dipartimenti: Neuroscienze

NanoCarb - Glyco-Nanoparticles for Applications in Advance Nanomedicine

Ente Finanziatore: Commissione Europea - MSCA-ITN

Area di Ricerca: Nanotecnologie

Altri dipartimenti: Neuroscienze


EOSC-Life - Providing an open collaborative space for digital biology in Europe

Ente Finanziatore: Commissione Europea

Area di Ricerca: Biologia digitale

The endoplasmic reticulum stress-responsive ERO1 triggers aggressive breast cancer

Ente Finanziatore: Associazione Italiana per la Ricerca sul Cancro (AIRC)

Area di Ricerca: Tumore della Mammella

Colchicine for Amyotrophic Lateral Sclerosis: a phase II, randomized, double blind, placebo controlled, multicenter clinical trial (Co-ALS)

Ente Finanziatore: Agenzia Italiana del Farmaco AIFA

Area di Ricerca: Malattie rare, Sclerosi Laterale Amiotrofica

Altri dipartimenti: Neuroscienze

Ricerca Finalizzata - RF-2013-02355259 - Cardiac amyloidosis: molecular mechanism and innovative therapies for a challenging aging-related cardiomyopathy

Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Area di Ricerca: Amiloidosi cardiaca

Altri dipartimenti: Med. Cardiovascolare

Ricerca Finalizzata - RF-2016-02361928 - Innovative therapeutic strategy targeting neurons with cholesterol in Huntington Disease: from preclinical studies to clinical trial readness

Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Area di Ricerca: Brain Disorder and Clinical Neuroscience

Ricerca Finalizzata - RF-2016-02362383 - All-trans retinoic acid in the neo-adjuvant treatment of estrogen-receptor positive breast cancer patients: a window of opportunity trial aimed at confirming the efficacy of the retinoid and at evaluating the diagnostic potential of a gene-expression model predicting sensitivity to the agent

Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Area di Ricerca: Tumore alla mammella

Altri dipartimenti: Oncologia

Ricerca Finalizzata - RF-2016-02361756 - Transition metal ions as a new therapeutic target for cardiac light chain amyloidosis

Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Area di Ricerca: Amiloidosi cardiaca

Ricerca Finalizzata - GR-2016-02361552 - Extracellular vesicles RNA: role in Amyotrophic Lateral Sclerosis pathogenesis and in patients profiling

Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Area di Ricerca: Sclerosi laterale amiotrofica

Altri dipartimenti: Oncologia

ERANET - E-Rare JTC - 2018 - MAXOMOD - Multi-omic analysis of axono-synaptic degeneration in motoneuron disease

Ente Finanziatore: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Area di Ricerca: Sclerosi laterale amiotrofica

Altri dipartimenti: Neuroscienze

The use of induced pluripotent stem cells (iPSC) for the definition of the pathogenic mechanisms underlying Spinal Muscular Atrophy

Ente Finanziatore: Fondazione Giovan Battista Baroni

Area di Ricerca: Atrofia muscolare spinale

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Head
Mario
Salmona
Head of Department
Biochimica e Farmacologia molecolare
mario.salmona@marionegri.it
Staff
Elena
Pozzoli
Assistant
Biochimica e Farmacologia molecolare
elena.pozzoli@marionegri.it
Pagina Italiano