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Biochemistry and Molecular Pharmacology

Head
Mario
Salmona
Head of Department
Biochimica e Farmacologia molecolare
mario.salmona@marionegri.it
Staff
Elena
Pozzoli
Assistant
Biochimica e Farmacologia molecolare
elena.pozzoli@marionegri.it

The research of the Department of Biochemistry and Molecular Pharmacology is aimed at the structural and functional study of specific and pharmacologically relevant gene products.

One of the principle goals is the identification of new proteins that could represent targets for drug therapy. Potential drug-protein interactions are studied also at the molecular level, using a wide variety of approaches ranging from studies performed on animal models to computational simulations.


ObJECTIVES

  • Development of efficient pharmacological strategies availing of pharmacological and functional studies (pharmacokinetics/pharmacodynamic), drugs repositioning, peptides therapy, multiomics approaches and machine learning in the study of patient selection, as crucial element for personalized medicine improvment, nanoparticles in nanomedicine and nanodiagnostics, differentiating agents for personalized treatment of breast and stomach cancer, analysis of nuclear receptor as pharmacological target in oncology, analysis of molecular interactions
  • Identification of molecular targets of protein-mediated diseases (genetic diseases and diseases caused by aberrant structure proteins)
  • Identification of protein markers in biological fluids, cells, tissues and extracellular vesicles both in patients and animal models

METHODOLOGICAL APPROACHES

  • Use of in vivo experimental animal models (vertebrates and invertebrates) to study peripheral amyloidosis, neurodegenerative and tumor diseases
  • Use of in vitro experimental models (cell lines, biopsies and pluripotent stem cells) to study peripheral amyloidosis, neurodegenerative and tumor diseases
  • Protein synthesis and purification
  • Use of drug quantification methods in biological matrices
  • Use of methods of interaction between proteins and biomolecules
  • Use of gene sequencing methods and next computational analysis of results
  • Use of "System Biology" approach to collect, integrate and analyze heterogeneous and multi-parameter data

Results

Development of new drugs for the treatment of acute myeloid leukemia

Current projects

NanoCarb - Glyco-Nanoparticles for Applications in Advance Nanomedicine

Sponsor: Commissione Europea - MSCA-ITN

Research area: Nanotechnology


EOSC-Life - Providing an open collaborative space for digital biology in Europe

Sponsor: Commissione Europea

Research area: Digital biology

The endoplasmic reticulum stress-responsive ERO1 triggers aggressive breast cancer

Sponsor: Associazione Italiana per la Ricerca sul Cancro (AIRC)

Research area: Breast cancer


Colchicine for Amyotrophic Lateral Sclerosis: a phase II, randomized, double blind, placebo controlled, multicenter clinical trial (Co-ALS)

Sponsor: Agenzia Italiana del Farmaco AIFA

Research area: Rare diseases, Amiotrophic Lateral Sclerosis

Ricerca Finalizzata - RF-2013-02356221 - Development of a nanoparticle-based pharmacological approach for amyotrophic lateral sclerosis

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Amiotrophic Lateral Sclerosis, Nanoparticles

Ricerca Finalizzata - RF-2013-02355259 - Cardiac amyloidosis: molecular mechanism and innovative therapies for a challenging aging-related cardiomyopathy

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Cardiac Amyoloidosis

Ricerca Finalizzata - RF-2016-02362383 - All-trans retinoic acid in the neo-adjuvant treatment of estrogen-receptor positive breast cancer patients: a window of opportunity trial aimed at confirming the efficacy of the retinoid and at evaluating the diagnostic potential of a gene-expression model predicting sensitivity to the agent

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Breast cancer

Ricerca Finalizzata - RF-2016-02361756 - Transition metal ions as a new therapeutic target for cardiac light chain amyloidosis

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Cardiac Amyoloidosis

Ricerca Finalizzata - GR-2016-02361552 - Extracellular vesicles RNA: role in Amyotrophic Lateral Sclerosis pathogenesis and in patients profiling

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Amiotrophic Lateral Sclerosis

ERANET - E-Rare JTC - 2018 - MAXOMOD - Multi-omic analysis of axono-synaptic degeneration in motoneuron disease

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Amiotrophic Lateral Sclerosis

The use of induced pluripotent stem cells (iPSC) for the definition of the pathogenic mechanisms underlying Spinal Muscular Atrophy

Sponsor: Fondazione Giovan Battista Baroni

Research area: Spinal muscular atrophy

A multicentric randomised pragmatic trial to compare the effectiveness of fingolimod versus dimethyl-fumarate on patient overall disease experience in relapsing-remitting multiple sclerosis: novel data to inform decision-makers

Sponsor: Patient-Centered Outcomes Research Institute (PCORI)

Research area: Multiple sclerosis

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Head
Mario
Salmona
Head of Department
Biochimica e Farmacologia molecolare
mario.salmona@marionegri.it
Staff
Elena
Pozzoli
Assistant
Biochimica e Farmacologia molecolare
elena.pozzoli@marionegri.it
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