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Cardiovascular Medicine

Head
Roberto
Latini
Head of Laboratory
Medicina Cardiovascolare
roberto.latini@marionegri.it
Staff
No items found.

The Department of Cardiovascular Medicine focuses on experimental and basic research area, as well as on the clinical and epidemiological evaluation of drugs.

It studies new diagnostic-therapeutic strategies and analyses risk factors for cardiovascular diseases.

ObJECTIVES

  • Improve the control of cardiovascular risk factors and lifestyles
  • Evaluate the efficacy of new drugs for cardiovascular prevention
  • Evaluate the translation of proven precautionary interventions in daily clinical practice
  • Depict epidemiology and drug-epidemiology of cardiovascular diseases
  • Improve treatments for patients with heart failure and diabetes or other comorbidities
  • Evaluate the predictive role of circulating biomarkers for the prevention of cardiotoxicity during chemotherapy
  • Evaluate the efficacy of a beta-blocker drug used fora rare disease, the familial Cerebral Cavernous angiomas (CCM)
  • Check the efficacy of human albumin used in septic shock and unravel the mechanisms of the possible benefit through circulating molecules analysis
  • Check the efficacy of new defibrillation methods and new neuro-protective interventions, such as argon, based on preclinical assessments of brain damage mechanisms after post-cardiac arrest resuscitation

METHODOLOGICAL APPROACHES

  • Controlled clinical trials and observational studies in collaboration with a large network of General Practitioners
  • Analysis of drug prescriptions and hospital admissions through the linkage of large administrative databases
  • In vivo study of mouse-rat-pig cardiac function through high-definition echocardiography, magnetic resonance imaging, electrocardiogram and invasive hemodynamics
  • Study of cardiac structure through histology and immunohistochemistry, with transmission electronic microscopy
  • Scientific and organizational coordination of a network of centers which are involved in clinical trials in cardiovascular field
  • Controlled clinical trials in collaboration with the Emergency system (112-118) and with therapies
  • Data base management of cardiological patients
  • Statistical analysis of experimental data and clinical trials
  • Use biological samples collected in the ISO9001 certified Biobank, whose material derives from different patient cohorts, for a total of more than 30000 subjects

Results

  • The studies named GISSI, performed with the participation of 90% of Italian Coronary Units, allowed us to halve mortality due to heart attack
  • Two recent studies, which showed the existence of new genes responsible for the development of coronary heart disease, caused by the concurrence of many genes, each responsible for a small effect

Current projects

SECURE - Secondary Prevention of Cardiovascular Disease in the Elderly, a prospective randomized clinical trial comparing a polypill versus standard of care treatment strategies in post MI elderly patients

Sponsor: Commissione Europea

Research area: Cardiovascular diseases


ESCAPE-NET - European Sudden Cardiac Arrest network: towards Prevention, Education and NEw Treatment

Sponsor: Commissione Europea

Research area: Cardiovascular diseases

Treat_CCM Clinical Trial - A multicenter randomized clinical trial on Propranolol in Cerebral Cavernous Malformation (CCM)

Sponsor: Agenzia Italiana del Farmaco AIFA

Research area: Rare diseases, CCM


Ricerca Finalizzata - GR-2011-02348099 - 13l optimization of treatment with inhaled argon to improve neurological outcome and survival after cardiac arrest

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Cardiovascular diseases

Ricerca Finalizzata - RF-2016-02361583 - Efficacy of Albumin Replacement and Balanced Crystalloid Solutions in Septic Shock (the ALBIOSS-BALANCED trial): a 2-by-2 factorial, investigator-initiated, open-label, multicenter, randomized, controlled trial.

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Septic shock

ERANET - ERA-CVD JTC - 2016 - LIPCAR-HF - LIPCAR, a prognostic marker of heart failure with reduced ejection fraction

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Cardiovascular diseases

Progetti di Rete IRCCS - Rete Cardiovascolare - Implementation of mobile Health and eHealth approaches for optimal cardiovascular prevention - IMPROVE Study

Sponsor: Ministero della Salute, DG Ricerca e Innovazione in Sanità

Research area: Cardiovascular prevention

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Head
Roberto
Latini
Head of Laboratory
Medicina Cardiovascolare
roberto.latini@marionegri.it
Staff
No items found.

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