Il Centro promuove e facilita, con le tecnologie di spettrometria di massa, una ricerca interdisciplinare per la salute e l’ambiente.
Il Centro gestisce la strumentazione basata sulla spettrometria di massa, attualmente presente nel Dipartimento, in modo da armonizzarne l’utilizzo in funzione del personale, della tecnologia e delle risorse economiche disponibili.
GC/MS
Agilent 5975C EIMSD con campionatore in spazio di testa
Agilent 5973 EI/CI MSD con sorgenti EI/CI
Thermo Finnigan Mat 95 XP Dioxin
HPLC/MS
Agilent 6410 - triplo quadrupolo
Sciex API 5500 - triplo quadrupolo
Shimadzu LC/MC 8060 - triplo quadruplo
ThermoScientific - LTQ XL Orbitrap
ThermoScientific - Orbitrap Q Exactive
MALDI TOF
AB Sciex4800 TOF/TOF
IMAGING CONSPETTROMETRIA DI MASSA
AB Sciex 4800 - MALDI in vuoto
Themo Orbitrap Q Exactive- MALDI a pressione atmosferica
SunChrom Sun Collect Matrix Sprayer
Open Source Arduino-based IMatrixSpray
PUBBLICAZIONI SELEZIONATE DEL CENTRO
Imaging con Spettrometria di Massa
- Giordano S, Morosi L, Veglianese P, Licandro SA, Frapolli R, Zucchetti M, Cappelletti G, Falciola L, Pifferi V, Visentin S, D’Incalci M, Davoli E. 3D Mass Spectrometry Imaging Reveals a Very Heterogeneous Drug Distribution in Tumors. Sci Rep 2016, 6, 37027.
- Davoli E, Zucchetti M, Matteo C, Ubezio P, D'Incalci M, Morosi L. The space dimension at the micro level: mass spectrometry imaging of drugs in tissues . Mass Spectrom Rev 2021, 40, 201–214.
- Giordano S, Takeda S, Donadon M, Saiki H, Brunelli L, Pastorelli R, Cimino M, Soldani C, Franceschini B, Di Tommaso L, Lleo A, Yoshimura K, Nakajima H, Torzilli G, Davoli E. Rapid automated diagnosis of primary hepatic tumour by mass spectrometry and artificial intelligence. Liver Int 2020 ; 40 : 3117-3124.
Metabolomica e Proteomica
- Caiola E, Colombo M, Sestito G, Lupi M, Marabese M, Pastorelli R, Broggini M, Brunelli L. Glutaminase Inhibition on NSCLC Depends on Extracellular AlanineExploitation. Cells. 2020 Jul 23;9(8):E1766.
- Ferrario M, Brunelli L, Su F, Herpain A, Pastorelli R. The Systemic Alterations of Lipids, Alanine-Glucose Cycle and Inter-Organ Amino Acid Metabolism in Swine Model Confirms the Role of Liver in Early Phase of Septic Shock. Front Physiol. 2019 Jan 28;10:11.
- Caiola E, Falcetta F, Giordano S, Marabese M, Garassino MC, Broggini M, Pastorelli R, Brunelli R. Co-occurring KRAS mutation/LKB1 loss in non-small cell lung cancer cells results in enhanced metabolic activity susceptible to caloric restriction: an in vitro integrated multilevel approach. Journal of Experimental & Clinical Cancer Research 2018. 37:302.
Chimica e Biochimica Analitica
- Bagnati R, Terzaghi E, Passoni A, Davoli E, Fattore E, Maspero A, Palmisano G, Zanardini E, Borin S, Di Guardo A. Identification of Sulfonated and Hydroxy-Sulfonated Polychlorinated Biphenyl (PCB) Metabolites in Soil: New Classes of Intermediate Products of PCB Degradation? Environ. Sci.Technol. 2019, 53 (18), 10601–10611.
- Passoni A, Favagrossa M, Colombo L, Bagnati R, Gobbi M, Diomede L, Birolini G, Di Paolo E, Valenza M, Cattaneo E, Salmona M. Efficacy of Cholesterol Nose-to-Brain Delivery for Brain Targeting in Huntington’s Disease. ACS Chem Neurosci 2020, 11 (3), 367–372.
- Bagnati R, Davoli E. Analytical methods for the detection of illicit drugs in wastewaters and surface waters In: Illicit drugs in the environment: Occurrence, analysis, and fate using mass spectrometry. Wiley, Hoboken 2011
Analisi Microinquinanti
- Teoldi F, Lodi M, Benfenati E, Colombo A, Baderna D. Air quality in the Olona Valley and in vitro human health effects. Sci Total Environ 2017; 579: 1929-1939.
- Colombo A, Bettinetti R, Strona G, Cambria F, Fanelli R, Zubair Z, Galli P. Maldives: Anarchipelago that burns. A first survey of PCDD/Fs and DL-PCBs from human activities. Sci Total Environ 2014 ; 497-498 : 499-50.
- Colombo A, Benfenati E, Bugatti SG, Lodi M, Mariani A, Musmeci L, Rotella G, Senese V Ziemacki G, Fanelli R. PCDD/Fs and PCBs in ambient air in a highly industrialized city in Northern Italy. Chemosphere 2013: 90: 2352-2357.
